Figure 8.

Histopathological damage after UUO: morphometry data. Morphometric analysis of cortical renal sections 10 days after UUO in obstructed kidneys (black bars) and contralateral unobstructed kidneys (white bars). Values are means ± SD of cell counts per hpf. Note that treatment with BX471 for 10 days as well as from days 6 to 10 significantly reduced the interstitial volume index and collagen index compared with vehicle controls. BX471 given from day 0 to 5 had no effect on interstitial volume and collagen index. The indices of tubular lumen and tubular cell damage were not affected by either treatment regimen.