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. 2002 Jan 15;109(2):161–168. doi: 10.1172/JCI14843

Figure 2.

Figure 2

A model of ITIM-related cellular regulation. Co-ligation of ITAM-containing activating receptors with ITIM-bearing inhibitory receptors facilitates the Src family PTK-dependent tyrosine phosphorylation of the ITIMs. For FcγRIIB, this creates high-affinity epitopes for SH2-containing SHIP and the subsequent hydrolysis of the membrane inositol phosphate PIP3. For killer cell Ig-like receptors (KIRs), the tyrosine-phosphorylated ITIMs recruit SH2-containing SHP-1 (and SHP-2), leading to a block in early PTK activation.