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. 2002 Feb 1;109(3):363–371. doi: 10.1172/JCI13462

Figure 4.

Figure 4

In vitro neutrophil degranulation and TNF-α production in DPPI–/– mice. (a) Purified PMNs (107/ml) were incubated with 50 ng/ml PMA for 15 minutes, and cell-free supernatants were analyzed by gelatin zymography. Note that DPPI–/– and WT PMNs released equivalent levels of MMP-9. (b) TNF-α production 90 minutes after intraperitoneal injection of 100 μg LPS. Open circles represent TNF-α levels prior to LPS injection. Serum TNF-α levels (filled circles) after LPS injection were equivalent in WT mice and DPPI–/– mice.