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. 2002 Feb 15;109(4):481–489. doi: 10.1172/JCI12867

Figure 5.

Figure 5

The polycystin-1 effect on branching morphogenesis and migration can be mimicked by a short segment (amino acids 4191–4302) of the cytoplasmic domain of human polycystin-1. (a) IMCD cells were transduced with retroviral vectors encoding either CD16.7 (white bars), CD16.7.PKD1 (full-length cytoplasmic domain of polycystin-1, gray bars) or CD16.7.PKD14191–4302 (black bars), and subjected to branching morphogenesis assays. Expression of the C-terminal 112 amino acids of polycystin-1 resulted in increased basal and HGF-stimulated branching morphogenesis that was indistinguishable from that observed with the full-length cytoplasmic domain. **P < 0.01; n = 3. (b) Expression of the C-terminal 112 amino acids of polycystin-1 initiate IMCD cell migration and augment HGF-stimulated migration. **P < 0.01; n = 3.