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The R4227X polycystin-1 nonsense mutation of patients with ADPKD abrogates branching morphogenesis. IMCD cells were transduced with a retrovirus expressing CD16.7 fused to the cytoplasmic tail of polycystin-1 (PKD14077–4302), or to cytoplasmic polycystin-1 truncated at R4227 (PKD14077–4227). A retrovirus expressing CD16.7 was used as a control. Truncation of the cytoplasmic tail of polycystin-1 at R4227 abrogated branching morphogenesis of IMCD cells. **P < 0.01.
