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. 2002 Feb 15;109(4):499–507. doi: 10.1172/JCI13200

Figure 3.

Figure 3

Ischemic preconditioning (PC) and PKCε transgenesis induce activation and translocation of PKCε. (a) Wild-type mice that underwent an ischemic PC protocol (six cycles of 4-minute coronary occlusion and 4-minute reperfusion) exhibited enhanced phosphorylation activity of PKCε (upper panel) concomitant with increased particulate expression of the PKCε protein (lower panel) when compared with wild-type mice that underwent a sham operation (control). Tissue samples were harvested 30 minutes after the last reperfusion or at corresponding times in controls. *P < 0.05 vs. control. (b) Transgenic mice carrying a cardiac-targeted active PKCε cDNA displayed increased PKCε protein and PKCε activity in the particulate fraction when compared with wild-type mice. Data are mean ± SEM. *P < 0.05 vs. wild-type.