Figure 3.

Atherosclerotic lesion size in gonadectomized NNee and nnee mice treated with a control pellet or an E2-containing pellet. Lower number in each bar is sample size (n). Upper number in each bar is mean lesion size (×10³ μm²), with SEM represented as a vertical line. In male and female mice of both genotypes, exogenous E2 treatment significantly reduces atherosclerotic lesion size. *P < 0.05 versus Gdx mice of the same sex and genotype (Student t test with Bonferroni correction for multiple comparisons).