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. 2002 Mar 1;109(5):661–670. doi: 10.1172/JCI13572

Figure 4.

Figure 4

CF and non-CF bronchiectasis sol-derived elastase disrupts human AM ingestion of apoptotic human PMNs. Human AMs were cocultured with apoptotic human PMNs following pretreatment with media (Control), 10% CF (a), or 10% non-CF bronchiectasis (BR) (b) sol with or without DMSO, DMP777 (20 μM), NEI (100 μM), CGI (10 μM), or NEI and CGI. Coculture was done in the presence of DMP777 (20 μM) to prevent carryover of elastase activity. The mean phagocytic index as percentage of control ± SEM is shown for three to four replicates per group. Control mean phagocytic index: (a) 7.9 ± 1.7; (b) 7.7 ± 1.4. *Groups indicated were significantly different from control (P < 0.05).