Figure 4.

(a) LVEDD measured by M-mode echocardiography in iNOS⁺/αMtTA⁺ mice and littermate controls. Animals were fed DOX (200 μg/ml in drinking water) to suppress transgene expression and released at 10 weeks of age (day 0). (b) Heart/body weight ratio in iNOS⁺/αMtTA⁺ mice (n = 3) and iNOS⁺/αMtTA^– littermates (n = 4). (c) H&E, picro-sirius red, and Movat’s staining of serial cardiac sections from an iNOS⁺/αMtTA⁺ mouse and control littermate.