Figure 3.

Blood pressure responses in α_1D^+/+ and α_1D^–/– mice. Phenylephrine (a), norepinephrine (b), angiotensin II or vasopressin (c) was injected intravenously as a bolus to male nonanesthetized α_1D^+/+ (open circles, n = 8) or α_1D^–/– mice (filled circles, n = 12) (12–18 weeks old). The effects on blood pressure are shown and expressed as the change in MAP (in mmHg). Responses to phenylephrine or norepinephrine in α_1D^–/– mice were significantly decreased at doses as indicated compared with the wild-type response. The maximal increase in blood pressure is shown. Points represent the mean ± SEM. *P < 0.05 as compared with α_1D^+/+ mice.