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. Author manuscript; available in PMC: 2006 Jul 17.
Published in final edited form as: J Mammary Gland Biol Neoplasia. 2004 Oct;9(4):297–310. doi: 10.1007/s10911-004-1402-z

Fig. 3.

Fig. 3

Cooperation between proliferative and survival signals results in filling of acinar lumen. Confocal sections of DAPI-stained day 20 structures formed by parental MCF-10As or cells overexpressing cyclin D1 or cyclin D1/Bcl-2 are shown. Inset, staining of cyclin D1 acini with DAPI (blue) and an antibody to the cleaved form of caspase-3 (green) reveals elevated levels of luminal apoptosis in these structures (13). The MCF-10A and cyclin D1 panels were reproduced from ref. (13).