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. 2002 Apr 1;109(7):931–937. doi: 10.1172/JCI14685

Figure 1.

Figure 1

IL-7 decreases TGF-β production by PFF in an IFN-γ–independent manner. (a andb) Primary fibroblasts from IPF patients (PFF, n = 5) or non-IPF subjects (NF, n = 5) were cultured in medium with or without IL-7 for 24 hours, and the culture supernatants were assayed for TGF-β by ELISA. IL-7 decreases TGF-β production in PFF, but not in NF. (c and d) While IFN-γ decreased TGF-β production in both NF and PFF, IL-7 decreased TGF-β production only in PFF. The addition of anti–IFN-γ antibody did not alter the capacity of IL-7 to decrease TGF-β, suggesting that IL-7 acts in an IFN-γ–independent manner. *P < 0.01.