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. 2002 Apr 15;109(8):1021–1030. doi: 10.1172/JCI13972

Figure 2.

Figure 2

Expression of p53 correlates with terminal epithelial differentiation. Consecutive tissue sections from a 5-day-old newborn rat kidney were immunostained for p53 (a), bradykinin B2R (b), AQP-2 (c), Na,K-ATPase-α1 (d), and AT1A (e). The bulk of p53 is concentrated in the DZ within both proximal and distal nephron segments. Similarly, the RFGs (B2R, AT1A, Na,K-ATPase-α1, and AQP-2) are expressed in the DZ. The NZ contains immature nephron elements and exhibits little immunoreactivity for p53 or RFGs.