Skip to main content
. 1999 Jan 5;96(1):79–84. doi: 10.1073/pnas.96.1.79

Figure 3.

Figure 3

sAC has two presumptive catalytic domains most closely related to bacterial AC catalytic domains. (A) Diagram of presumptive catalytic domains of sAC aligned with catalytic portions of various bacterial ACs. The relative similarities are “expect values” taken directly from a blast search of the sAC protein vs. the nonredundant GenBank database. These values estimate the statistical significance of the match by specifying the number of matches expected to occur by chance. Relative locations of the catalytic domains within the bacterial ACs are represented as shaded boxes (24–26) and are aligned under the sAC presumptive catalytic domain with greater similarity. (B) Phylogenetic relationship between catalytic domains from a variety of ACs aligned by using clustalw (dna*) represented as an unrooted dendogram constructed by using fitch (phylip 3.5) (27) with Anabaena spirulina cyaC used as the outgroup. Accession numbers for the aligned sequences are AC1 (bovine Type I: M25579), AC9 (mouse Type IX: Z50190), Dd ACA (Dictyostelium ACA: Q03100), Dd ACG (Dictyostelium ACG: Q03101), Anabaena sp. cyaA (2126532), Anabaena sp. cyaB1 (1754638), Anabaena sp. cyaB2 (1754640), Anabaena sp. cyaC (2575807), Anabaena cy. cya (2126532), Stigmatella cyaA (729248), Stigmatella cyaB (729250), Sc CYR1 (Saccharomyces cerevisiae CYR1: M12057), and Sp CYR1 (Schizosaccharomyces pombe CYR1: M24942).