Figure 4.

CD4⁺ donor T cells induce GVHD mortality in old allogeneic recipients. Old (triangles, n = 8) and young (squares, n = 10) B6D2F1 mice received 11 Gy TBI and were injected with 5 × 10⁶ TCD BM and 1 × 10⁶ CD4⁺ splenic T cells from allogeneic B6 mice. *P < 0.005, old versus young mice. Filled inverted triangle and open inverted triangle represent old (n = 8) B6D2F1 and young (n = 10) B6D2F1 mice, respectively, receiving 5 × 10⁶ TCD BM cells and 1 × 10⁶ CD8⁺ donor T cells.