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Generation of Tg rats expressing an antisense GHS-R gene. (a) Schematic structure of the antisense GHS-R transgene. (b) Gross appearance of a 6-week-old Tg rat and its non-Tg littermate. (c) Expression of the antisense GHS-R gene in Tg rats. Lane 1, hypothalamus; lane 2, heart; lane 3, liver; lane 4, kidney; lane 5, testis; lane 6, pituitary.
