Figure 6.
Induction of ex vivo NK cell cytotoxic activity after in vivo administration of IL-2 to a patient with NEMO exon 4 mutation. Patient 1 was treated with 1 × 106 U/m2 of human recombinant IL-2 by continuous intravenous infusion for 5 days. NK cytotoxicity was determined ex vivo by lysis of 51Cr-labeled target cells before treatment, immediately after (0 wk), 1 week after, 2 weeks after, 3 weeks after, or 4 weeks after treatment (circles). K562 lysis mediated by PBMCs from untreated control donors (squares) was performed in parallel. Different control donors were used in each assay.