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The effect of endogenous IL-2 on long-term cardiac allograft survival induced by CD28-B7 blockade in a MHC-mismatched (BALB/c into C57BL/6) combination (a) or a minor-mismatched (129 into C57BL/6) combination (b). Wild-type or IFN-γ–/– recipients were treated with or without CTLA4Ig as described in Methods.
