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. 2002 Jun 1;109(11):1437–1444. doi: 10.1172/JCI15051

Figure 2.

Figure 2

MMP-7 expression in metaplastic ducts of the mouse pancreas. MMP-7 immunoreactivity in (a) normal mouse pancreas (bar, 200 μm); (b) metaplastic ducts after chronic expression of TGF-α (scale bar, 30 μm); and (c and d) metaplastic ducts after PDL (scale bars represent 200 μm and 50 μm, respectively). (e) Bright-field and (f) dark-field views of in situ hybridization for MMP-7 in metaplastic ducts after PDL (scale bar, 100 μm). (g) First panel shows immunoblot for MMP-7 expression using lysates collected 5 days after ductal ligation. The pro (27 kDa) and active (act; 18 kDa) forms of MMP-7 are indicated. The second panel shows immunoblot for pro MMP-7 (27 kDa) using lysates from pancreata before ligation (day 0) and 3, 5, 7, and 10 days after ductal ligation, as indicated. Protein loading was visualized with Fast Green stain (Load).