Suppression of EAE induced with the PLP 139-151 epitope by different random copolymers. SJL/J mice were co-injected subcutaneously with 50 μg of PLP 139-151 peptide and 500 μg of the random copolymers FAK, YFAK (0.2:0.8), YFAK (0.5:0.5), YFAK (0.8:0.2), or Cop 1, or with PLP 139-151 alone. The progression of the disease was monitored for the appearance of clinical symptoms on a daily basis. Results represent the mean daily score. Five to nine mice per group were used in each of two independent identical experiments that were combined.