Figure 2.

Roles of acetylation/deacetylation of p53 and NF-κB in transcriptional regulation. (a) Interaction of p53 with acetylases facilitates alteration of chromatine structure by histone acetylation and association of transcription complex machinery; p53 is itself subject to acetylation. NF-κB becomes attached to acetyltransferases containing complexes facilitating an “open chromatine” configuration and the binding of transcription factors and RNA polymerase II. (b) Deacetylases regulate p53 and NF-κB- mediated transcription, possibly by inducing a “repressed chromatin” configuration.