Figure 3.

(A) Trophoblast tissues from Dlx3 +/+ (Left) and −/− (Right) littermates. Histology of sagittal sections of +/+ and −/− placentas at E9.5, E10.5, and E12.5 stained with hematoxylin and eosin. al, allantois; la, labyrinthine layer; sp, spongiotrophoblast layer, gi, giant trophoblast layer; d, decidua. (Scale bar = 250 μm.) (B) Higher magnification of boxed areas in A for panels +/+ and −/− at E12.5. Arrowhead indicates maternal enucleated blood cell and arrow indicates fetal blood cell. A few blood vessels are apparent in the compacted labyrinthine and spongiotrophoblast layers in the −/− E12.5 placenta. (Scale bar = 40 μm.)