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Systemic therapy with PPARγ ligands inhibits primary tumor growth. After tumors were 100–200 mm3 in size, rosiglitazone treatment (100 mg/kg/d) was initiated (day 0). On the last day of treatment, the statistical difference between control (Ctr; blue) and treated (pink) groups was determined by Student’s t test. (a) Glioblastoma (U87) (P < 0.01). (b) LLC (P < 0.001). (c) Liposarcoma (LS) (P < 0.001). (d) Rhabdomyosarcoma (RMS) (P < 0.001).
