Figure 1.

The positions of residues mutated are indicated on the DR1 structure. The amino acid in Aβ^s is noted on the right of the residue number, and the amino acid in Aβ^u is noted on the left of the residue number. Residues E74β, L35α, F28α, and T86β were mutated singly. Polymorphic residues that differ between Aβ^s and Aβ^u were grouped into HVRs and were mutated on the Aβ^s backbone to those of Aβ^u, either as a single HVR or as combinations of HVRs. HVR1, residues 8β, 9β, 12β, 13β, and 14β; HVR2, residues 26β and 28β; HVR3, residue 70β; and HVR4, residues 81β, 85β, 86β, 88β, and 89β.