Figure 3.

NOEY2-induced growth inhibition of ovarian and breast cancer cell lines. (A) Colony formation after NOEY2 cDNA transfection. NOEY2 in the sense orientation inhibited growth of OVCA433, OVCA429, Hey, and SKBr3 (P < 0.001). (B) Inhibition of cyclin D1 promoter activity in Saos-2, NIH 3T3, SKBr3, and Hey cells. Luciferase activity in cells transfected with the sense construct was expressed as a percentage of the activity in cells transfected with the antisense vector. The results are from representative experiments performed in triplicate.