Figure 5.

Protection against influenza virus in JAK3 BMT mice. The HKx31-infected mice were followed long term to determine the effects of JAK3 gene transfer on survival. All mice from the JAK3 −/− group (includes mock BMT mice and untransplanted JAK3 −/− mice) became progressively ill and died by day 29 after infection. By contrast, roughly 90% of JAK3 BMT mice survived the challenge and lived long term. The relative survival of JAK3 BMT mice was the same as that seen after transplant of normal wild-type BM (+/+ BMT, Expt #1).