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Two-Component Phosphotransfer Schemes.
(A) A basic prokaryotic two-component system with a sensor His kinase and a response regulator. H and D represent the conserved phospho-accepting His and Asp residues involved in phosphorelay signaling.
(B) A multistep phosphorelay system involving a hybrid sensor kinase, with input, transmitter, and receiver domains, a His-containing phosphotransfer protein (Hpt), and a response regulator.
