Figure 2.
BR Biosynthesis Pathway.
A simplified scheme of the BR biosynthesis pathway including steps of early and late C-6 oxidation that lead to the synthesis of BL (Noguchi et al., 2000; Shimada et al., 2001). Mutations in genes coding for key biosynthetic enzymes are in bold. det-2, DEETIOLATED-2, steroid 5α reductase (Li et al., 1996); dwf4, DWARF4 cytochrome P450 CYP90B, C-22 hydroxylase (Choe et al., 1998); cpd, CONSTITUTIVE PHOTOMORPHOGENIC and DWARFISM cytochrome P450 CYP90A, C-23 hydroxylase (Szekeres et al., 1996); dx, DWARF cytochrome P450 CYP85, C-6 oxidase (Bishop et al., 1996, 1999; Shimada et al., 2001); DDWF, DARK-INDUCED dwf-LIKE-1, cytochrome P450 CYP92A6, C-2 hydroxylase (Kang et al., 2001).