. Author manuscript; available in PMC: 2006 Jul 18.

Published in final edited form as: Science. 2005 Mar 10;308(5720):385–389. doi: 10.1126/science.1109557

Table 1.

Odds ratios and population attributable risks (PARs) for AMD. The dominant odds ratio and PAR compare the likelihood of AMD in individuals with at least one copy of the risk allele versus individuals with no copy of the risk allele. The recessive odds ratio and PAR compare the likelihood of AMD in individuals with two copies of the risk allele versus individuals with no more than one copy of the risk allele. The population frequencies for the risk genotypes are taken from the CEU HapMap population (CEPH collection of Utah residents of northern and western European ancestry).

Attribute	rs380390 (C/G)	rs1329428 (C/T)
Risk allele	C	C
Allelic association χ² nominal P value	4.1 × 10⁻⁸	1.4 × 10⁻⁶
Odds ratio (dominant) (95% CI)	4.6 (2.0–11)	4.7 (1.0–22)
PAR (95% CI)	70% (42–84%)	80% (0–96%)
Frequency in HapMap CEU	0.70	0.82
Odds ratio (recessive) (95% CI)	7.4 (2.9–19)	6.2 (2.9–13)
PAR (95% CI)	46% (31–57%)	61% (43–73%)
Frequency in HapMap CEU	0.23	0.41