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. 1999 Jan 5;96(1):254–259. doi: 10.1073/pnas.96.1.254

Figure 4.

Figure 4

Nissl staining of hippocampal CA1 sector 7 days after 12 min of transient forebrain ischemia sufficient to induce isoelectric EEG. Intravenous treatment immediately after the ischemic injury and daily for 7 days consisted of unconjugated BDNF at a dose of 250 μg/kg per day (A and C) or BDNF-PEG 2000-biotin (250 μg/kg per day) conjugated to OX26/SA (B and D). The neuronal cell density is markedly reduced in the animals treated with unconjugated BDNF, but is normalized by the treatment with the BDNF-PEG-OX26 conjugate. [Magnification bars: (A) 21 μm, and (C) 212 μm.]