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(A) Inhibition of serum TxB2, an index of COX-1 activity ex vivo in volunteers 4 hr after receiving placebo, 800 mg ibuprofen, or various doses of celecoxib. ∗, P < 0.05; ∗∗, P < 0.01 for comparisons with placebo. (B) The relationship between log plasma concentration of celecoxib taken 2, 4, 6, and 24 hr after dosing and inhibition of serum TxB2 expressed as the percentage change from baseline values. A shallow but variable dose response effect is evident (see Results).
