Table 1.
Summary of the functional features of Sp1-like/KLF family members
| Protein* | KLF number | Species | Chromosomal localization† | Transcriptional activity (and functional domains) | Expression pattern | Interacting coactivatorand/or corepressor | Cellular functions |
| Sp1 | - | Human, mouse, rat and Drosophila | 12q13 | Activator (Q-rich domains) | Ubiquitous | CRSP, p300/CBP, TAFII130 | Embryogenesis |
| Sp2 | - | Human, mouse and rat | 17q21 | Unknown (Q-rich domain) | Unknown | Unknown | |
| Sp3 | - | Human, mouse and rat | 2q31 | Activator and/or repressor (Q-rich domains) | Ubiquitous | Unknown | Unknown |
| Sp4 | - | Human, mouse and rat | 7p15 | Activator (Q-rich domains) | Brain-enriched | Unknown | Post-natal survival and male fertility |
| mSp5 | - | Mouse | Unknown | Ubiquitous | Unknown | Unknown | |
| Sp6 | KLF14 | Human and mouse | 17q21 | Activator | Ubiquitous | Unknown | Unknown |
| EKLF | KLF1 | Human and mouse | 19p13 | Activator (acidic domain) | Erythroid and mast cells | p300/CBP, PCAF, SWI/SNF and mSin3A | Erythropoiesis |
| LKLF | KLF2 | Human and mouse | 19p13 | Activator (acidic domain) | Lung, blood vessels, lymphocytes | Unknown | Blood vessel, lung development, T-cell survival |
| BKLF | KLF3 | Human, mouse and rat | 4p14 | Activator/repressor (PVDLS/T motif) | Erythroid tissue- and brain-enriched | CtBP2 | Unknown |
| GKLF | KLF4 | Human, mouse, rat and zebrafish | 9q31 | Activator and/or repressor (acidic domain) | Gut-enriched | p300/CBP | Anti-proliferation, survival |
| IKLF | KLF5 | Human, mouse and rat | 13q21 | Activator | Gut and epithelial tissues | Unknown | Cell growth |
| CPBP | KLF6 | Human and mouse | 10p15 | Activator | Ubiquitous | Unknown | Putative tumor suppressor |
| UKLF | KLF7 | Human and mouse | 2q32 | Activator (acidic domain) | Ubiquitous | Unknown | Cell-cycle arrest |
| BKLF3 | KLF8 | Human | Xp11 | Repressor (PVDLS/T motif) | Ubiquitous | CtBP2 | Unknown |
| BTEB1 | KLF9 | Human, mouse and rat | 9q13 | Activator/repressor (SID) | Ubiquitous | mSin3A | Neurite outgrowth and carcinogen metabolism |
| TIEG1 | KLF10 | Human | 8q22 | Repressor (SID, R2, R3) | Ubiquitous | mSin3A | Apoptosis, anti-proliferation |
| TIEG2/FKLF | KLF11 | Human | 2p25 | Activator and/or repressor (SID, R2, R3) | Ubiquitous | mSin3A | Anti-proliferation |
| AP-2rep | KLF12 | Human, mouse, rat and zebrafish | 13q21 | Repressor (PVDLS/T motif) | Brain, kidney, liver and lung | CtBP1 | Unknown |
| BTEB3/RFLAT-1/FKLF-2 | KLF13 | Human, mouse and rat | 15q12 | Activator/repressor (SID, R2 and R3) | Ubiquitous | mSin3A, p300/CBP and PCAF | Anti-proliferation and carcinogen metabolism |
| KKLF | KLF15 | Human, mouse and rat | 3q13 | Repressor | Ubiquitous | Unknown | Unknown |
| BTEB4/mDRRF | KLF16 | Human and mouse | 19q13 | Repressor (SID) | Ubiquitous | mSin3A | Carcinogen metabolism |
| BTEB5 | - | Human | 7 | Unknown | Unknown | Unknown | Unknown |
*Original name with which the protein was first published. †Chromosomal localization data refer to the human genes and have been obtained from the human genome database of the National Center for Biotechnology Information (NCBI) [57].