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. 2006 Jul 20;116(8):2297–2305. doi: 10.1172/JCI27920

Figure 1. Properties of the PA2794 locus.

Figure 1

(A) Sequence predictions for PA2794. Shown are the results of structural prediction and sequence similarity searching techniques. The gene PA2794 is depicted 3 times, and shaded regions demonstrate distinct functional predictions. Regions are indicated using amino acid positions. Predicted transmembrane (TM) regions are shown first. These predictions were made using the programs TMPred (http://www.ch.embnet.org/software/TMPRED_form.html) and TMAP (http://bioweb.pasteur.fr/seqanal/interfaces/tmap.html). The second gene depiction shows the region most similar to other sialidase genes. Lighter gray shading indicates the region predicted by BLAST analysis. For an inclusive definition of the boundaries of this region, we used the most extreme amino- and carboxyterminal positions of BLAST alignments for the first 50 hits that were also labeled as sialidase or neuraminidase genes. The darker shading corresponds to the sialidase region predicted by the SMART program (http://smart.embl-heidelberg.de/). The third gene depiction shows the region similar to autotransporter genes. This region was determined by the BLAST alignment with a putative autotransporter (Magn03008734, GenBank accession no. ZP_00054112) from the Magnetospirillum magnetotacticum genome. This region had an E value score of 6 × 10–4 in our BLAST search. (B) Predicted PAO1 neuraminidase amino acid sequence. ASP boxes are shaded gray.