Figure 3. Lmna^HG/HG mice are small and have poorly mineralized bone.

(A and B) Photographs of 17-day-old Lmna^+/+ (A) and Lmna^HG/HG (B) mice. The Lmna^HG/HG mouse had a spontaneous fracture in the left forelimb (red arrow). (C–F) Surface renderings of μCT scans of the skull (performed at exactly the same threshold) for a 17-day-old Lmna^HG/HG mouse (D and F) and littermate Lmna^+/+ mouse (C and E). (C and D) Top view of skulls. The Lmna^HG/HG skull is misshapen, poorly mineralized, and exhibits incomplete fusion of the cranial sutures (red arrow). (E and F) Lateral view of skulls. The Lmna^HG/HG skull is misshapen, with a small mandible (upper red arrow) and a short lower incisor (lower red arrow).