Effects of synthetic polypeptides on PI3-K and p38 MAP
kinase expression. Neutrophils were incubated (37°C) with
medium control, fMLP (5 × 10−8 M), or 10 nM
(Pro-Pro-Gly)5, (Pro-Pro-Gly)10, (Pro-Hyp-Gly)5, or
(Pro-Hyp-Gly)10 for 2 hours (PI3-K) or 5 minutes
(p38, phospho-p38). (a) PI3-K, (b) p38, (c) phospho-p38, (d)
protein expressions were measured using western blotting
and quantified by densitometry. Time course of phospho-p38 protein
expression in response to (Pro-Pro-Gly)5. Western blots were
scanned by densitometry and data presented as relative intensity
units. One representative experiment of 3 is shown for each
analysis.