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. 2006 Jul 7;4:e016. doi: 10.1621/nrs.04016

Figure 2. Modulation of ER and AhR signaling via dioxin dependent interaction of ER with AhR.

Figure 2

The association of ER with activated AhR can be viewed as two separate pathways. 1. Activated AhR recruits unliganded or liganded ERα away from ER regulated genes to AhR regulated genes, inhibiting estrogen signaling. The shuttling via the AhR may serve as a mechanism to regulate ER protein levels. 2. ERα has been shown to modulate AhR-dependent transcription, suggesting that ERα is an important regulator of AhR activity.