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Schematic diagram of the mtDNA-CR. The functional sequences are indicated with boxes. Dashed arrows point to H-strand origin of replication 1 and 2 (OH1 and OH2). The arrows pointing left and right show transcription orientation of H- and L-strand promoters (PH and PL). Arrows below the line indicate the heteroplasmic nucleotide positions associated with aging. TAS, termination association sequence; CSB I, II, III, conserved sequence block I, II, and III; Tfam, Tfam binding sites.
