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. 2003 Feb 24;100(5):2209–2214. doi: 10.1073/pnas.0438037100

Figure 1.

Figure 1

(A) HBsAg constructs used in this paper. 2x35S, enhanced cauliflower mosaic virus (CaMV) 35S promoter; TEV, tobacco etch virus 5′ UTR; S, soybean vegetative storage protein vspA signal peptide (VSPαS); L, vspA signal peptide with putative vacuolar targeting signal (VSPαL); sHBsAg, synthetic plant optimized HBsAg gene; K, KDEL ER retention signal; VSP 3′, soybean vspB gene 3′ element. (B) VSPαS and VSPαL amino acid sequences with predicted cleavage sites between positions 18 and 19 (AWQ-CH) and positions 21 and 22 (CHA-YD), respectively.