Table 3.
Gene array analysis for adipogenesis, osteogenesis and myogenesis pathways
| GeneID | Name | Probe_ID | Fold change | |
| YT/YU | OT/OU | |||
| Cluster A | ||||
| Angiogenesis | ||||
| 114111 a | vascular endothelial growth factor | 1368463_at | 3.452121 | 1.502053 |
| 24617 a | Serine/cysteine proteinase inhibitor1 | 1368519_at | 5.822078 | 0.845776 |
| 25261 a | Inhibitor of DNA binding 1, helix-loop-helix protein | 1387028_a_at | 3.49452 | 0.986531 |
| 29452 a | Endothelial PAS domain protein 1 | 1369703_at | 5.615 | 1 |
| 64032 a | connective tissue growth factor | 1367631_at | 2.58613 | 1.079194 |
| 84353 b | beta-catenin | 1369733_at | 2.459261 | 1.906824 |
| Bone Remodeling | ||||
| 24477 | integrin binding sialoprotein | 1368416_at | 7.7875 | 1 |
| 56813 | parathyroid hormone receptor 1 | 1370259_a_at | 2.66125 | 1.123853 |
| 59328 | MAD homolog 5 (Drosophila)* | 1369276_at | 2.14625 | 1.970041 |
| 79110 | matrix extracellular phosphoglycoprotein | 1387330_at | 3.37375 | 0.997506 |
| Cluster C | ||||
| Cytoskeleton & Muscle Development | ||||
| 24582 ac | myosin heavy chain 11 | 1370896_a_at | 5.571237 | 4.653653 |
| 24851 ac | tropomyosin 1, alpha | 1370288_a_at | 4.89204 | 5.13257 |
| 25365 | Actin, gamma 2 | 1386869_at | 4.126485 | 5.083472 |
| 29437 ac | Actin alpha 1 | 1369928_at | 17.85533 | 9.397908 |
| 64362 ac | Desmin | 1367600_at | 2.398671 | 2.356318 |
| 114489 d | dystroglycan 1 | 1389105_at | 5.441386 | 7.678867 |
| 303468 bd | Sarcoglycan | 1372240_at | 2.9525 | 2.708798 |
| 25485 | myosin IC | 1369779_at | 5.11 | 2.61875 |
| 81531 | profilin II | 1367970_at | 3.62625 | 4.4225 |
| 24170 | Adducin 1, alpha | 1388487_at | 2.475238 | 2.510223 |
| Cell growth & Cell Cycle | ||||
| 24842 | tumor protein p53 | 1367830_a_at | 2.264291 | 2.543204 |
| 64457 d | N-myc downstream regulated 4 | 1370229_at | 4.279081 | 3.103067 |
| 29576 d | WNT1 inducible signaling pathway protein 2 | 1369484_at | 7.956218 | 2.918245 |
| 24183 | adenylate kinase 1 | 1370011_at | 4.118338 | 4.754549 |
| 25163 | cyclin dependent kinase inhibitor 2A | 1369194_a_at | 14.86273 | 8.253055 |
| 50594 | neuroblastoma, suppression of tumorigenicity 1 | 1387004_at | 3.827506 | 2.863581 |
| 58919 | cyclin D1 | 1371150_at | 3.147613 | 2.447929 |
| 64363 | v-raf murine sarcoma 3611 viral oncogene homolog 1 | 1388305_at | 2.02 | 2.018793 |
| 83570 | c-fos induced growth factor (vascular endothelial growth factor D) | 1387709_at | 11.6725 | 3.355 |
| 94201 | cyclin-dependent kinase 4 | 1372739_at | 2.388806 | 2.154783 |
| Cluster D | ||||
| Adipocyte Differentiation | ||||
| 24252 | CCAAT/enhancer binding protein, alpha | 1369658_at | 0.460345 | 0.627943 |
| 25664 | peroxisome proliferator activated receptor, gamma | 1369179_a_at | 0.291579 | 0.79108 |
| Cluster F | ||||
| Lipid Binding & Transport | ||||
| 140868 | fatty acid binding protein 5 | 1370281_at | 0.144064 | 0.4143 |
| 170538 | protein kinase C, delta | 1387114_at | 0.365549 | 0.470085 |
| 25023 | protein kinase C, beta 1 | 1370585_a_at | 0.028032 | 0.061769 |
| 25056 | retinol binding protein 1 | 1367939_at | 0.468695 | 0.471976 |
| 25728 | apolipoprotein E | 1370862_at | 0.308694 | 0.087332 |
| 25292 | apolipoprotein C-I | 1368587_at | 0.175235 | 0.329354 |
| 29184 | cd36 antigen | 1386901_at | 0.055742 | 0.035525 |
| 29510 | phosphatidylcholine transfer protein | 1387058_at | 0.346607 | 0.226442 |
| 79124 | ZAP 36/annexin IV | 1389305_at | 0.488443 | 0.480585 |
| 79451 | adipocyte protein aP2 | 1368271_a_at | 0.039507 | 0.01239 |
| Catabolism & Lysosomal Enzymes | ||||
| 117033 ac | matrix metalloproteinase 12 | 1368530_at | 0.02401 | 0.214259 |
| 171052 ac | matrix metalloproteinase 13 | 1388204_at | 0.155018 | 0.195806 |
| 25335 ac | matrix metalloproteinase 7 | 1368766_at | 0.150338 | 0.189753 |
| 24331 ac | elastase 1 | 1387819_at | 0.108743 | 0.2376 |
| 25166 ac | caspase 1 | 1369186_at | 0.255206 | 0.175345 |
| 171329 ac | ubiquitin specific protease 15 | 1370460_at | 0.295028 | 0.444408 |
| 24539 ac | lipoprotein lipase | 1386965_at | 0.016611 | 0.039975 |
| 54249 bd | Adipsin | 1388602_at | 0.18685 | 0.047754 |
| 313387 bd | ubiquitin specific protease 1 | 1376687_at | 0.417153 | 0.373377 |
| 24944 ac | lysosomal membrane glycoprotein 2 | 1370010_at | 0.430907 | 0.347294 |
| Ras protein signal transduction | ||||
| 114203 | adaptor protein with pleckstrin homology and src homology 2 domains | 1368605_at | 0.2262 | 0.175548 |
| 24525 | Kirsten rat sarcoma viral oncogene homologue 2 (active) | 1370035_at | 0.312723 | 0.375405 |
| 24605 | neuroblastoma RAS viral (v-ras) oncogene homolog | 1372032_at | 0.191657 | 0.238384 |
| 81504 | growth factor receptor bound protein 2 | 1368386_at | 0.373241 | 0.484997 |
| Defense Response | ||||
| 113959 | complement component 5, receptor 1 | 1368742_at | 0.234295 | 0.239768 |
| 116591 | Fc receptor, IgG, low affinity III | 1367850_at | 0.292948 | 0.310885 |
| 24223 a | beta-2 microglobulin | 1371440_at | 0.13671 | 0.16094 |
| 24494 ac | interleukin 1 beta | 1398256_at | 0.055097 | 0.172791 |
| 56822 ac | CD86 antigen | 1387627_at | 0.206497 | 0.402268 |
| 25599 ac | CD74 antigen | 1367679_at | 0.011698 | 0.040091 |
| 60350 ac | CD14 antigen | 1368490_at | 0.469431 | 0.412767 |
| 24930 a | CD8 antigen, alpha chain | 1369877_at | 0.36815 | 0.4273 |
| 24931 a | CD8 antigen, beta chain | 1387739_at | 0.203248 | 0.376336 |
| 24932 ac | CD4 antigen | 1369483_at | 0.204226 | 0.301498 |
The fold change are of treated versus untreated cells from young (3 month) or old (15 month) rats. In genes that have multiple probe sets, a representative probe set was displayed.
a) gene was selected with the relevant function in both rat genes and mouse orthologs
b) gene was selected with the relevant function in mouse orthologs,
c) gene was selected with the relevant function in both rat genes and human orthologs
d) gene was selected with the relevant function in human orthologs,
*) MAD homolog 5 appears also under the function of angiogenesis