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. 2006 Jun 28;397(Pt 2):297–304. doi: 10.1042/BJ20051362

Figure 1. Comparison of the human, murine, rat and toad Fn14 deduced amino acid sequences.

Figure 1

The human (Homo sapiens; GenBank® accession no. NM_016639), murine (Mus musculus; NM_013749), rat (Rattus norvegicus; NM_181086) and toad (X. laevis; AY458020) Fn14 sequences are aligned. Conserved residues are boxed and the numbers to the right refer to the last amino acids in each row. The six cysteine residues within the extracellular domain are shown in boldface, the signal peptidase (SP) cleavage site is indicated, and the transmembrane (TM) domain is boxed with a dotted line. The nine murine Fn14 residues that were mutated in the present study are indicated with a black box above the alignment.