Table 1.

IC50, ID50 and DEFs of the different cell lines. Sensitivity of different cell lines for gemcitabine (indicated by IC50 values) and radiotherapy (indicated by ID50 values) alone and the radiosensitising effect of gemcitabine represented by dose enhancement factors (DEF). (mean ± S.D.).

Cell line	IC50 (nM)	ID50 (Gy)	DEF 1 nM	DEF 2 nM	DEF 4 nM	DEF 6 nM	DEF 8 nM
ECV304	3.05 ± 0.49	3.37 ± 0.40	1.37 ± 0.06	2.41 ± 0.24	3.21 ± 0.25	3.64 ± 0.40	n.a.
FaDu	4.90 ± 0.46	3.09 ± 0.39	1.03 ± 0.04	1.22 ± 0.17	1.80 ± 0.26	2.37 ± 0.52	n.a.
H292	7.99 ± 0.77	4.00 ± 0.86	1.08 ± 0.10	1.23 ± 0.20	1.58 ± 0.22	2.07 ± 0.55	2.46 ± 0.82
A549	9.01 ± 0.89	4.51 ± 0.70	1.00 ± 0.04	1.21 ± 0.17	1.89 ± 0.51	2.39 ± 0.57	2.77 ± 0.26
CAL-27	8.92 ± 1.59	3.52 ± 0.88	1.06 ± 0.07	1.08 ± 0.04	1.49 ± 0.21	2.06 ± 0.06	2.51 ± 0.21
MCF-7	6.94 ± 2.03	4.96 ± 1.27	1.24 ± 0.06	1.45 ± 0.27	1.63 ± 0.13	2.55 ± 0.34	n.a.
HT-29	7.75 ± 1.61	5.64 ± 1.02	1.12 ± 0.21	1.30 ± 0.10	1.62 ± 0.04	2.39 ± 0.21	n.a.
Cell line	IC50 (nM)	ID50 (Gy)	DEF 7 nM	DEF 15 nM	DEF 35 nM	DEF 50 nM	DEF 100 nM
Panc-1	77.8 ± 9.1	2.92 ± 0.35	1.20 ± 0.10	1.50 ± 0.19	1.55 ± 0.19	1.83 ± 0.20	1.56 ± 0.08

n.a. not analysed