Table 2.

Comparison of HSGAG binding loop regions in different FGFs

FGF	Loop 1	Loop 2–S3D–Loop 3
1	CSNG	LKKNGSCKRGPRTHYGQKAIL
2	CKNG	LKRTGQYKLGSKTGPGQKAIL
4	CNVG	LGKNGKTKKGNRVSPTMKVTH
7	CRTQ	LNQKGLPVKGKKTKKEQKTAH
9	CRTG	LNKDGTPREGTRTKRHQKFTH

Sequence of the loop regions that were structurally superimposed is shown, where the HSGAG-binding basic residues are indicated in bold. The putative HSGAG-binding residues in FGF-4, -7, and -9 were identified by using the FGF–HSGAG cocrystal structures as a guiding framework.