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. Author manuscript; available in PMC: 2006 Jul 21.
Published in final edited form as: J Org Chem. 2005 Aug 19;70(17):6842–6847. doi: 10.1021/jo0508853

Scheme 1.

Scheme 1

aReagents and conditions: (a) 6 N HCl, 107 °C, 18.5 h; (b) solvent partitioning, 6 N HCl/EtOAc; (c) CD3OD, 65 h; (d) PPTS, 2,2-dimethoxypropane, DMF, 45 °C (30 min) -> 60 °C (1.5 h); (e) 2 N HCl in MeOH,60 °C, 15.5 h; (f) H O, reflux, 60 h. b bData reproduced from ref. 55.