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An aspect of the mechanism of immunosuppression by FK506 revealed by the present experiments. The FAP48–FKBP complex up-regulates IL2 production in activated Jurkat T cells. First step: The addition of FK506 breaks up the FAP48–FKBP complex, leading to an IL2 production decrease. Second step: The FKBP–FK506 interacts with calcineurin (CaN), therefore blocking IL2 synthesis.
