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. Author manuscript; available in PMC: 2006 Jul 22.
Published in final edited form as: Circulation. 2004 Aug 9;110(8):904–910. doi: 10.1161/01.CIR.0000139333.83620.5D

Figure 7.

Figure 7

Effect of ranolazine to suppress d-sotalol-induced early afterdepolarizations (EAD) in M cell and Purkinje fiber preparations. A: Shown are superimposed transmembrane action potentials recorded from a Purkinje fiber preparation in the presence of IKr block (100 μM d-sotalol), and following addition of increasing concentrations of ranolazine (5 and 10 μM) in the continued presence of d-sotalol. [K+]o=3 mM. BCL=8000 ms and B: Superimposed transmembrane action potentials recorded from an M cell preparation under control conditions, in the presence of IKr block (100 μM d-sotalol), and following increasing concentrations of ranolazine (5, 10, and 20 μM) in the continued presence of d-sotalol. BCL=2000 ms.