TABLE 1.

Effects of ranolazine on phase 0 amplitude, resting membrane potential (RMP), and overshoot of action potential in M cell and epicardial preparations at a BCL of 500 ms.

	Ranolazine Concentration (μM)
M Cell
	Control	1	5	10	50	100
Amplitude	107±6	109±4	114±4	113±4	104±3	91±8*
RMP	−86±2	−86±1	−86±1	−88±1	−84±2	−82±3
Overshoot	21±6	23±5	27±3	25±3	19±1	9±6

Epicardial Cell
	Control	1	5	10	50	100
Amplitude	95±2	93±2	101±1	94±2	86±6	93±2
RMP	−84±2	−84±2	−89±1	−88±1	−86±1	−85±2
Overshoot	11±1	10±2	12±1	8±2	0±6	8±4

Data are all in mV and expressed as mean±SEM, n=5 for all,

^*- p<0.05 vs. control