TABLE 2.
COX2 inhibitor neuroprotection: DFU reduced colocalization of activated caspase-3 and neuN at 72 hours postinjurya
|
Cortexc |
Hippocampusc |
|||||
|---|---|---|---|---|---|---|
| Treatmentb | Cingulate | Parietal | CA1 | CA2 | CA3 | Dentate |
| Injured/vehicle | 14 ± 2 | 7.8 ± 2.3 | 7.0 ± 1.7 | 11 ± 3 | 7.0 ± 2.7 | 7.3 ± 0.9 |
| Injured/DFU | 3.8 ± 1.4 | 0 | 3.2 ± 1.5 | 14 ± 5 | 10 ± 3 | 4.0 ± 1.4 |
| Analysis of variance P value | 0.0071 | 0.0140 | 0.1208 | 0.6552 | 0.4035 | 0.1280 |
a
DFU, 5,5-Dimethyl-3(3-fluorophenyl)-4(4-methylsulfonyl)phenyl-2(3H)-furanone.
b
DFU treatment was 10 mg/kg initiated 10 minutes before injury. There was no colocalized staining in any of the sham animals at the 72-hour time point.
c
Average counts of colocalized cells from the reference space (bregma −2.8 to −4.3 mm).