Table 4.

Codon sites where positive selection was inferred by the original and modified SG methods and by the ML method, and condition (3) occurred in the original SG method in the E1 and E2 glycoproteins of HCV

		Selection
Protein	Position	Originala	Modifiedb	ML	Function	Reference(s)
E1	19	No	No	Positive	TCE	Lechmann et al. 1996
	28	Positive	No	No	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	40	Positive	No	No	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	42	(3)c	No	Positive	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	44	Positive	Positive	No	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	60	Positive	Positive	No	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	62	Positive	No	No	BCE	Zibert et al. 1999
	65	Positive	Positive	No	BCE	Zibert et al. 1999
	108	Positive	Positive	No	BCE	Zibert et al. 1999
	123	Positive	Positive	Positive	BCE, TCE	Lechmann et al. 1996; Zibert et al. 1999
	139	No	No	Positive	TCE	Lechmann et al. 1996
	154	Positive	Positive	No	TCE	Lechmann et al. 1996
E2	1	(3)	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	3	(3)	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	4	Positive	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	5	No	No	Positive	HVR1, BCE	Zibert et al. 1997
	8	(3)	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	9	No	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	12	(3)	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	14	(3)	Positive	Positive	HVR1, BCE	Zibert et al. 1997
	16	(3)	No	Positive	HVR1, BCE	Zibert et al. 1997
	17	No	No	Positive	HVR1, BCE	Zibert et al. 1997
	21	(3)	No	Positive	HVR1, BCE, TCE	Zibert et al. 1997; Gruner et al. 2000
	22	(3)	Positive	Positive	HVR1, BCE, TCE	Zibert et al. 1997; Gruner et al. 2000
	25	No	No	Positive	HVR1, BCE, TCE	Zibert et al. 1997; Gruner et al. 2000
	27	No	No	Positive	HVR1, BCE, TCE	Zibert et al. 1997; Gruner et al. 2000
	51	(3)	Positive	Positive	BCE	Zibert et al. 1999
	61	No	No	Positive	BCE	Zibert et al. 1999
	63	Positive	Positive	Positive	BCE	Zibert et al. 1999
	81	Positive	Positive	Positive	BCE	Zibert et al. 1999
	83	No	No	Positive	BCE	Zibert et al. 1999
	92	No	No	Positive	BCE	Zibert et al. 1999
	95	(3)	Positive	Positive	BCE	Zibert et al. 1999
	97	Positive	Positive	Positive	BCE	Zibert et al. 1999
	109	No	No	Positive	BCE	Zibert et al. 1999
	118	Positive	Positive	Positive	BCE	Zibert et al. 1999
	141	No	Positive	No	BCE	Zibert et al. 1999
	145	Positive	Positive	Positive	BCE	Zibert et al. 1999
	242	Positive	Positive	No	BCE, TCE	Zibert et al. 1999; Erickson et al. 2001
	258	No	Positive	Positive	BCE	Zibert et al. 1999
	337	Positive	Positive	No	BCE	Zibert et al. 1999
	407	No	No	Positive	TCE	Erickson et al. 2001

^aOriginal SG method.

^bModified SG method.

^cCondition (3) occurred.