Figure 4.

The methylation state of Axin^Fu and A^vy in mature sperm reflects the methylation state of the alleles in the somatic tissue of the animal. (A) DNA from mature sperm of penetrant (P) and silent (S) 8-week-old Axin^Fu/+ males was subjected to bisulfite sequencing. One line represents the sequence from one clone and the methylation profile of the LTR/intron 6 region (refer to Fig. 1D) in one mature sperm. Each block of lines represents the methylation data of sperm DNA obtained from one adult male mouse. (B) DNA from mature sperm of yellow (Y) and agouti (A) 8-week-old A^vy/a males was subjected to bisulfite sequencing. All the CpG sites shown for the A^vy allele are contained within the LTR.