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. 2003 Feb 24;100(5):2538–2543. doi: 10.1073/pnas.0436776100

Figure 5.

Figure 5

Transgenerational epigenetic inheritance is influenced by strain background. (A) Avy/a C57BL/6J males of the indicated phenotypes (eight yellow sires and six agouti sires) were mated to 129P4/RrRk females (129P4/RrRk mice are Aw/Aw at the agouti locus; Avy is dominant over Aw), and the offspring's coat color was recorded. The number of total Avy/Aw progeny of each cross is indicated (n); mice that did not carry the Avy allele have been omitted from the pedigree. The phenotype of the sire influences the range of phenotypes in the offspring (P < 0.05). (B) AxinFu/+ 129P4/RrRk sires of the indicated phenotypes (five penetrant sires and five silent sires) were mated to C57BL/6J dams (+/+ at the axin locus), and the F1 offspring's tail phenotype was recorded. The number of total AxinFu/+ progeny from each cross is indicated (n); +/+ mice have been omitted from the pedigree. The proportions of phenotypes arising from penetrant and silent sires do not differ significantly (P = 0.48).