Figure 5.

Transgenerational epigenetic inheritance is influenced by strain background. (A) A^vy/a C57BL/6J males of the indicated phenotypes (eight yellow sires and six agouti sires) were mated to 129P4/RrRk females (129P4/RrRk mice are A^w/A^w at the agouti locus; A^vy is dominant over A^w), and the offspring's coat color was recorded. The number of total A^vy/A^w progeny of each cross is indicated (n); mice that did not carry the A^vy allele have been omitted from the pedigree. The phenotype of the sire influences the range of phenotypes in the offspring (P < 0.05). (B) Axin^Fu/+ 129P4/RrRk sires of the indicated phenotypes (five penetrant sires and five silent sires) were mated to C57BL/6J dams (+/+ at the axin locus), and the F₁ offspring's tail phenotype was recorded. The number of total Axin^Fu/+ progeny from each cross is indicated (n); +/+ mice have been omitted from the pedigree. The proportions of phenotypes arising from penetrant and silent sires do not differ significantly (P = 0.48).